Drug interactions
Progesterone micronized + Trimipramine
Severity: Minor
Progesterone micronized and Trimipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sex hormones have been reported to alter tricyclic antidepressant exposure and response. The effect of oral micronized progesterone on trimipramine is poorly documented, and progesterone's own sedative effect may add to drowsiness.
What this interaction means in plain words
Progesterone micronized and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible hormonal modulation of hepatic metabolism, plus additive sedation; not well established.
What to do
No routine change is needed. Monitor for excess sedation or altered antidepressant response and adjust the dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Progesterone micronized with Trimipramine?
MediHelp rates the interaction as minor. Progesterone micronized and Trimipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sex hormones have been reported to alter tricyclic antidepressant exposure and response. The effect of oral micronized progesterone on trimipramine is poorly documented, and progesterone's own sedative effect may add to drowsiness.
How serious is the interaction between Progesterone micronized and Trimipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for excess sedation or altered antidepressant response and adjust the dose if needed.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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