Drug interactions
Propafenone + Quetiapine
Severity: Major
Propafenone and Quetiapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so giving them together may raise the risk of torsades de pointes, especially with electrolyte disturbance, bradycardia or structural heart disease. Propafenone also has proarrhythmic potential of its own.
What this interaction means in plain words
Propafenone and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Propafenone belongs to Cardiovascular; Quetiapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and conduction.
What to do
Avoid the combination when possible; if it is needed, obtain a baseline and follow-up ECG and correct potassium and magnesium. Consider an alternative antipsychotic with less QT effect.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Propafenone with Quetiapine?
MediHelp rates the interaction as major. Propafenone and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so giving them together may raise the risk of torsades de pointes, especially with electrolyte disturbance, bradycardia or structural heart disease. Propafenone also has proarrhythmic potential of its own.
How serious is the interaction between Propafenone and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; if it is needed, obtain a baseline and follow-up ECG and correct potassium and magnesium. Consider an alternative antipsychotic with less QT effect.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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