Drug interactions
Propafenone + Riociguat
Severity: Moderate
Propafenone and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Riociguat is cleared by several CYP enzymes, and propafenone is not a strong inhibitor of these pathways, so any pharmacokinetic effect is likely small. Both can lower blood pressure, and the combination may add to hypotension in some patients.
What this interaction means in plain words
Propafenone and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propafenone belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
Possible modest reduction in riociguat metabolism and additive hypotensive effects.
What to do
Monitor blood pressure and symptoms of hypotension when starting or adjusting either drug. Reduce the riociguat dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Propafenone with Riociguat?
MediHelp rates the interaction as moderate. Propafenone and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Riociguat is cleared by several CYP enzymes, and propafenone is not a strong inhibitor of these pathways, so any pharmacokinetic effect is likely small. Both can lower blood pressure, and the combination may add to hypotension in some patients.
How serious is the interaction between Propafenone and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or adjusting either drug. Reduce the riociguat dose if hypotension develops.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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