Drug interactions
Propafenone + Umeclidinium-vilanterol
Severity: Moderate
Propafenone and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone is a class 1C antiarrhythmic that can prolong QRS and QT intervals and is proarrhythmic. Vilanterol may add to arrhythmic risk through adrenergic stimulation and hypokalemia.
What this interaction means in plain words
Propafenone and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propafenone belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive proarrhythmic effects: sodium channel blockade with QT effects plus beta-agonist stimulation and potassium lowering.
What to do
Monitor ECG and serum potassium, especially in patients with structural heart disease. Report palpitations or syncope promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Frequently asked questions
Can I take Propafenone with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Propafenone and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone is a class 1C antiarrhythmic that can prolong QRS and QT intervals and is proarrhythmic. Vilanterol may add to arrhythmic risk through adrenergic stimulation and hypokalemia.
How serious is the interaction between Propafenone and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium, especially in patients with structural heart disease. Report palpitations or syncope promptly.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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