Drug interactions
Propafenone + Venetoclax
Severity: Moderate
Propafenone and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone may inhibit intestinal and cellular P-glycoprotein efflux, raising venetoclax exposure. Higher venetoclax levels can increase the risk of neutropenia, infections and tumor lysis syndrome, particularly during dose initiation.
What this interaction means in plain words
Propafenone and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propafenone belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.
Why it happens
Propafenone inhibits P-glycoprotein, reducing efflux of venetoclax and increasing its systemic exposure.
What to do
Where possible choose an antiarrhythmic that does not inhibit P-gp. If combined, reduce the venetoclax dose per labeling for P-gp inhibitors and monitor blood counts and for tumor lysis syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Propafenone with Venetoclax?
MediHelp rates the interaction as moderate. Propafenone and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone may inhibit intestinal and cellular P-glycoprotein efflux, raising venetoclax exposure. Higher venetoclax levels can increase the risk of neutropenia, infections and tumor lysis syndrome, particularly during dose initiation.
How serious is the interaction between Propafenone and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an antiarrhythmic that does not inhibit P-gp. If combined, reduce the venetoclax dose per labeling for P-gp inhibitors and monitor blood counts and for tumor lysis syndrome.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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