Drug interactions
Propantheline + Trimipramine
Severity: Moderate
Propantheline and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propantheline is a quaternary antimuscarinic, and trimipramine has marked antimuscarinic activity. Together they can produce excessive anticholinergic effects including dry mouth, constipation, urinary retention, tachycardia and paralytic ileus.
What this interaction means in plain words
Propantheline and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic effects such as constipation and urinary retention, and reduce doses if they occur. Avoid in patients with obstructive gastrointestinal or urinary disease or narrow-angle glaucoma.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Propantheline with Trimipramine?
MediHelp rates the interaction as moderate. Propantheline and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propantheline is a quaternary antimuscarinic, and trimipramine has marked antimuscarinic activity. Together they can produce excessive anticholinergic effects including dry mouth, constipation, urinary retention, tachycardia and paralytic ileus.
How serious is the interaction between Propantheline and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as constipation and urinary retention, and reduce doses if they occur. Avoid in patients with obstructive gastrointestinal or urinary disease or narrow-angle glaucoma.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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