Drug interactions
Propylhexedrine + Terbutaline
Severity: Moderate
Propylhexedrine and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propylhexedrine is a sympathomimetic decongestant, and combining it with terbutaline can add to cardiovascular stimulation. This may cause palpitations, tachycardia, tremor and increased blood pressure, particularly in patients with heart disease or hypertension.
What this interaction means in plain words
Propylhexedrine and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propylhexedrine belongs to Respiratory; Terbutaline belongs to Respiratory.
Why it happens
Additive sympathomimetic activity through direct beta-agonism and indirect norepinephrine release.
What to do
Monitor heart rate and blood pressure and avoid the combination in patients with significant cardiovascular disease or uncontrolled hypertension. Counsel patients to report palpitations or chest pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Other interactions of Propylhexedrine
- Isocarboxazid + Propylhexedrine Contraindicated
- Phenelzine + Propylhexedrine Contraindicated
- Linezolid + Propylhexedrine Major
- Propylhexedrine + Selegiline Major
- Propylhexedrine + Tranylcypromine Major
- Adrenaline-articaine + Propylhexedrine Moderate
Frequently asked questions
Can I take Propylhexedrine with Terbutaline?
MediHelp rates the interaction as moderate. Propylhexedrine and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propylhexedrine is a sympathomimetic decongestant, and combining it with terbutaline can add to cardiovascular stimulation. This may cause palpitations, tachycardia, tremor and increased blood pressure, particularly in patients with heart disease or hypertension.
How serious is the interaction between Propylhexedrine and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and avoid the combination in patients with significant cardiovascular disease or uncontrolled hypertension. Counsel patients to report palpitations or chest pain.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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