Drug interactions
Protriptyline + Sevoflurane
Severity: Moderate
Protriptyline and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline is a tricyclic antidepressant that can prolong the QT interval and cause arrhythmias, and sevoflurane also prolongs the QT interval. Both may increase sedation and cause hypotension, although protriptyline is less sedating than other tricyclics.
What this interaction means in plain words
Protriptyline and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and CNS depression, with tricyclic effects on cardiac conduction.
What to do
Check a baseline ECG and electrolytes, and monitor the ECG during anesthesia. Avoid other QT-prolonging drugs and arrhythmogenic sympathomimetics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Protriptyline with Sevoflurane?
MediHelp rates the interaction as moderate. Protriptyline and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline is a tricyclic antidepressant that can prolong the QT interval and cause arrhythmias, and sevoflurane also prolongs the QT interval. Both may increase sedation and cause hypotension, although protriptyline is less sedating than other tricyclics.
How serious is the interaction between Protriptyline and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and electrolytes, and monitor the ECG during anesthesia. Avoid other QT-prolonging drugs and arrhythmogenic sympathomimetics.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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