Drug interactions
Protriptyline + Tedizolid
Severity: Moderate
Protriptyline and Tedizolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protriptyline inhibits serotonin and norepinephrine reuptake, and tedizolid is a weak reversible MAO inhibitor. Serotonin syndrome is theoretically possible, though clinical evidence with tedizolid is limited.
What this interaction means in plain words
Protriptyline and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Potential additive serotonergic effect from weak MAO inhibition and reuptake inhibition.
What to do
Monitor for serotonin syndrome symptoms and blood pressure changes during co-therapy. Consider an alternative antibiotic if the patient has other serotonergic risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tedizolid
- Bupropion + Tedizolid Major
- Cyproheptadine + Tedizolid Major
- Deferiprone + Tedizolid Major
- Isocarboxazid + Tedizolid Major
- Meperidine + Tedizolid Major
- Methamphetamine + Tedizolid Major
Frequently asked questions
Can I take Protriptyline with Tedizolid?
MediHelp rates the interaction as moderate. Protriptyline and Tedizolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protriptyline inhibits serotonin and norepinephrine reuptake, and tedizolid is a weak reversible MAO inhibitor. Serotonin syndrome is theoretically possible, though clinical evidence with tedizolid is limited.
How serious is the interaction between Protriptyline and Tedizolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin syndrome symptoms and blood pressure changes during co-therapy. Consider an alternative antibiotic if the patient has other serotonergic risk factors.
What other medicines interact with Tedizolid?
MediHelp also lists interactions of Tedizolid with, for example, Bupropion, Cyproheptadine, Deferiprone. The full list is on the Tedizolid page.
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