Drug interactions
Quazepam + Tramadol
Severity: Major
Quazepam and Tramadol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concomitant opioids and benzodiazepines can cause profound sedation, respiratory depression, coma and death. Quazepam is a long-acting benzodiazepine hypnotic whose effects add to those of tramadol.
What this interaction means in plain words
Quazepam and Tramadol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression via opioid and GABA-A receptor effects.
What to do
Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression and counsel on avoiding alcohol.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Quazepam with Tramadol?
MediHelp rates the interaction as major. Quazepam and Tramadol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Concomitant opioids and benzodiazepines can cause profound sedation, respiratory depression, coma and death. Quazepam is a long-acting benzodiazepine hypnotic whose effects add to those of tramadol.
How serious is the interaction between Quazepam and Tramadol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve concurrent use for patients without alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression and counsel on avoiding alcohol.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
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