Drug interactions
Quazepam + Trazodone
Severity: Moderate
Quazepam and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so combining them can increase drowsiness, impair psychomotor performance and raise the risk of falls. Next-day impairment is a particular concern with long-acting quazepam.
What this interaction means in plain words
Quazepam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through sedative antihistaminic and alpha-1 blocking effects of trazodone and GABA-A potentiation by quazepam.
What to do
Use the lowest effective doses and counsel the patient to avoid driving and alcohol. Monitor older patients closely for oversedation and falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Quazepam with Trazodone?
MediHelp rates the interaction as moderate. Quazepam and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so combining them can increase drowsiness, impair psychomotor performance and raise the risk of falls. Next-day impairment is a particular concern with long-acting quazepam.
How serious is the interaction between Quazepam and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and counsel the patient to avoid driving and alcohol. Monitor older patients closely for oversedation and falls.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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