Drug interactions
Quetiapine + Saxagliptin-metformin
Severity: Moderate
Quetiapine and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is associated with hyperglycemia, weight gain and dyslipidemia, which can undermine glycemic control in patients treated with saxagliptin-metformin. Diabetic patients may need treatment intensification.
What this interaction means in plain words
Quetiapine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through antipsychotic-induced insulin resistance and weight gain.
What to do
Monitor fasting glucose and HbA1c after starting quetiapine and periodically afterward. Adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Quetiapine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is associated with hyperglycemia, weight gain and dyslipidemia, which can undermine glycemic control in patients treated with saxagliptin-metformin. Diabetic patients may need treatment intensification.
How serious is the interaction between Quetiapine and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting quetiapine and periodically afterward. Adjust antidiabetic therapy as needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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