Drug interactions
Quetiapine + Sertraline
Severity: Moderate
Quetiapine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and quetiapine is associated with torsades de pointes mainly in overdose or when combined with other risk factors. Sertraline has a low QT liability, so the combined risk is usually small but real in susceptible patients.
What this interaction means in plain words
Quetiapine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive QTc prolongation through pharmacodynamic effects on cardiac repolarization.
What to do
Check baseline ECG and electrolytes (potassium, magnesium) in patients with cardiac risk factors and correct abnormalities. Avoid adding further QT-prolonging drugs and reassess if palpitations or syncope occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Sertraline?
MediHelp rates the interaction as moderate. Quetiapine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, and quetiapine is associated with torsades de pointes mainly in overdose or when combined with other risk factors. Sertraline has a low QT liability, so the combined risk is usually small but real in susceptible patients.
How serious is the interaction between Quetiapine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes (potassium, magnesium) in patients with cardiac risk factors and correct abnormalities. Avoid adding further QT-prolonging drugs and reassess if palpitations or syncope occur.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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