Drug interactions
Quetiapine + Sumatriptan
Severity: Moderate
Quetiapine and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a triptan with an antipsychotic has been associated in theory with serotonin syndrome, and with neuroleptic malignant syndrome. Documented cases are rare, and the combination is often used in practice for migraine in patients with psychiatric illness.
What this interaction means in plain words
Quetiapine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Sumatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic activity (5-HT1B/1D agonism with quetiapine's 5-HT2A antagonism and dopamine blockade); the mechanism is not firmly established.
What to do
Counsel the patient to report agitation, tremor, sweating, fever or muscle rigidity. Evaluate promptly if these appear and stop one or both drugs if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Quetiapine with Sumatriptan?
MediHelp rates the interaction as moderate. Quetiapine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a triptan with an antipsychotic has been associated in theory with serotonin syndrome, and with neuroleptic malignant syndrome. Documented cases are rare, and the combination is often used in practice for migraine in patients with psychiatric illness.
How serious is the interaction between Quetiapine and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report agitation, tremor, sweating, fever or muscle rigidity. Evaluate promptly if these appear and stop one or both drugs if toxicity is suspected.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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