Drug interactions
Quetiapine + Tiotropium
Severity: Minor
Quetiapine and Tiotropium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine, through its metabolite norquetiapine, has anticholinergic activity that may add to tiotropium's effects. This can increase dry mouth, constipation, urinary retention and sedation or confusion in older patients.
What this interaction means in plain words
Quetiapine and Tiotropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Quetiapine belongs to Central Nervous System; Tiotropium belongs to Respiratory.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects and review total anticholinergic burden in older adults.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tiotropium
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Tiotropium?
MediHelp rates the interaction as minor. Quetiapine and Tiotropium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quetiapine, through its metabolite norquetiapine, has anticholinergic activity that may add to tiotropium's effects. This can increase dry mouth, constipation, urinary retention and sedation or confusion in older patients.
How serious is the interaction between Quetiapine and Tiotropium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and review total anticholinergic burden in older adults.
What other medicines interact with Tiotropium?
MediHelp also lists interactions of Tiotropium with, for example, Glycopyrrolate inhaled, Indacaterol-glycopyrronium, Revefenacin. The full list is on the Tiotropium page.
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