Drug interactions
Quetiapine + Tolazamide
Severity: Moderate
Quetiapine and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine can cause hyperglycemia and worsen glucose tolerance, which may counteract the glucose-lowering effect of tolazamide. Glycemic control may deteriorate in patients with diabetes.
What this interaction means in plain words
Quetiapine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Tolazamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: quetiapine-related insulin resistance and metabolic effects oppose sulfonylurea action.
What to do
Monitor blood glucose and HbA1c when starting or adjusting quetiapine. Increase the antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Quetiapine with Tolazamide?
MediHelp rates the interaction as moderate. Quetiapine and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine can cause hyperglycemia and worsen glucose tolerance, which may counteract the glucose-lowering effect of tolazamide. Glycemic control may deteriorate in patients with diabetes.
How serious is the interaction between Quetiapine and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c when starting or adjusting quetiapine. Increase the antidiabetic therapy if control worsens.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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