Drug interactions
Quetiapine + Tolbutamide
Severity: Moderate
Quetiapine and Tolbutamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine can cause hyperglycemia and impair glucose tolerance, which may reduce the effectiveness of tolbutamide. Diabetic patients may need closer glycemic follow-up.
What this interaction means in plain words
Quetiapine and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Tolbutamide belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism: quetiapine-related insulin resistance and metabolic effects oppose sulfonylurea action.
What to do
Monitor blood glucose and HbA1c at baseline and during treatment. Adjust the antidiabetic regimen as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Tolbutamide
- Glyburide-metformin + Tolbutamide Major
- Insulin degludec-liraglutide + Tolbutamide Major
- Aceclofenac + Tolbutamide Moderate
- Acemetacin + Tolbutamide Moderate
- Acetylsalicylic acid + Tolbutamide Moderate
- Albiglutide + Tolbutamide Moderate
Frequently asked questions
Can I take Quetiapine with Tolbutamide?
MediHelp rates the interaction as moderate. Quetiapine and Tolbutamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine can cause hyperglycemia and impair glucose tolerance, which may reduce the effectiveness of tolbutamide. Diabetic patients may need closer glycemic follow-up.
How serious is the interaction between Quetiapine and Tolbutamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c at baseline and during treatment. Adjust the antidiabetic regimen as required.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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