Drug interactions
Quetiapine + Tranylcypromine
Severity: Moderate
Quetiapine and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination may add serotonergic and dopamine-blocking effects, so serotonin toxicity or neuroleptic malignant syndrome is theoretically possible. Quetiapine can also add sedation and orthostatic hypotension to the MAO inhibitor's blood pressure effects.
What this interaction means in plain words
Quetiapine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects from MAO inhibition and quetiapine's receptor antagonism.
What to do
Titrate quetiapine slowly from a low dose. Monitor orthostatic blood pressure, sedation, temperature and neuromuscular signs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Tranylcypromine?
MediHelp rates the interaction as moderate. Quetiapine and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination may add serotonergic and dopamine-blocking effects, so serotonin toxicity or neuroleptic malignant syndrome is theoretically possible. Quetiapine can also add sedation and orthostatic hypotension to the MAO inhibitor's blood pressure effects.
How serious is the interaction between Quetiapine and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate quetiapine slowly from a low dose. Monitor orthostatic blood pressure, sedation, temperature and neuromuscular signs.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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