Drug interactions
Quetiapine + Umeclidinium-vilanterol
Severity: Moderate
Quetiapine and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine can prolong the QT interval, and beta-2 agonists such as vilanterol may add to cardiac effects including tachycardia and hypokalemia. Together they may modestly increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Quetiapine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive pharmacodynamic effects on cardiac repolarization and heart rate.
What to do
Use at recommended inhaler doses and monitor ECG in patients with other QT risk factors. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Quetiapine and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine can prolong the QT interval, and beta-2 agonists such as vilanterol may add to cardiac effects including tachycardia and hypokalemia. Together they may modestly increase the risk of ventricular arrhythmias.
How serious is the interaction between Quetiapine and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use at recommended inhaler doses and monitor ECG in patients with other QT risk factors. Correct potassium and magnesium abnormalities.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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