Drug interactions
Quetiapine + Zafirlukast
Severity: Moderate
Quetiapine and Zafirlukast: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine is extensively metabolized by CYP3A4, and zafirlukast may modestly raise its levels. This may increase sedation, orthostatic hypotension and QT effects.
What this interaction means in plain words
Quetiapine and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated quetiapine metabolism by zafirlukast.
What to do
Monitor for sedation and orthostatic hypotension after starting zafirlukast. Reduce the quetiapine dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Zafirlukast?
MediHelp rates the interaction as moderate. Quetiapine and Zafirlukast can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine is extensively metabolized by CYP3A4, and zafirlukast may modestly raise its levels. This may increase sedation, orthostatic hypotension and QT effects.
How serious is the interaction between Quetiapine and Zafirlukast?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension after starting zafirlukast. Reduce the quetiapine dose if adverse effects occur.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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