Drug interactions
Quinacrine + Risperidone
Severity: Minor
Quinacrine and Risperidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinacrine may inhibit CYP2D6, which is the main enzyme converting risperidone to its active metabolite 9-hydroxyrisperidone. Exposure to the parent drug could rise, though the total active moiety changes less. Clinical data are limited.
What this interaction means in plain words
Quinacrine and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible CYP2D6 inhibition by quinacrine reducing risperidone metabolism.
What to do
Monitor for extrapyramidal symptoms, sedation and hypotension. Reduce the risperidone dose if adverse effects emerge.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Quinacrine with Risperidone?
MediHelp rates the interaction as minor. Quinacrine and Risperidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinacrine may inhibit CYP2D6, which is the main enzyme converting risperidone to its active metabolite 9-hydroxyrisperidone. Exposure to the parent drug could rise, though the total active moiety changes less. Clinical data are limited.
How serious is the interaction between Quinacrine and Risperidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and hypotension. Reduce the risperidone dose if adverse effects emerge.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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