Drug interactions
Quinapril + Temsirolimus
Severity: Moderate
Quinapril and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both mTOR inhibitors and ACE inhibitors are associated with angioedema, and using them together raises the risk of this reaction. Angioedema can involve the face, tongue or airway and may be serious.
What this interaction means in plain words
Quinapril and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effect on angioedema: ACE inhibition reduces bradykinin breakdown while mTOR inhibitors appear to further predispose to angioedema.
What to do
Counsel patients to report swelling of the lips, tongue, face or throat immediately. Stop quinapril and switch to a different antihypertensive class if angioedema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Quinapril with Temsirolimus?
MediHelp rates the interaction as moderate. Quinapril and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both mTOR inhibitors and ACE inhibitors are associated with angioedema, and using them together raises the risk of this reaction. Angioedema can involve the face, tongue or airway and may be serious.
How serious is the interaction between Quinapril and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report swelling of the lips, tongue, face or throat immediately. Stop quinapril and switch to a different antihypertensive class if angioedema occurs.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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