Drug interactions
Quinidine + Regorafenib
Severity: Moderate
Quinidine and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine may inhibit CYP3A4 and raise regorafenib concentrations while lowering its active metabolites, giving an unpredictable net effect. Regorafenib is hepatotoxic, so altered exposure is of concern.
What this interaction means in plain words
Quinidine and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Regorafenib belongs to Oncology.
Why it happens
CYP3A4 inhibition by quinidine alters regorafenib metabolism; quinidine is only a moderate-to-weak CYP3A4 inhibitor.
What to do
Monitor liver function tests and tolerability, and consider an alternative antiarrhythmic if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Regorafenib
Frequently asked questions
Can I take Quinidine with Regorafenib?
MediHelp rates the interaction as moderate. Quinidine and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine may inhibit CYP3A4 and raise regorafenib concentrations while lowering its active metabolites, giving an unpredictable net effect. Regorafenib is hepatotoxic, so altered exposure is of concern.
How serious is the interaction between Quinidine and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and tolerability, and consider an alternative antiarrhythmic if feasible.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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