Drug interactions
Quinidine + Saxagliptin-metformin
Severity: Moderate
Quinidine and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a cationic drug that competes with metformin for renal tubular secretion and may raise metformin exposure. Quinidine is also a CYP3A4 substrate and weak inhibitor, so the effect on saxagliptin is likely small and the legacy strong-inhibitor dose limit does not clearly apply.
What this interaction means in plain words
Quinidine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Competition for renal tubular secretion via OCT2 and MATE transporters, and weak CYP3A4 inhibition.
What to do
Monitor glucose and renal function, and watch for metformin adverse effects such as gastrointestinal upset or lactic acidosis. Consider reducing metformin dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Quinidine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine is a cationic drug that competes with metformin for renal tubular secretion and may raise metformin exposure. Quinidine is also a CYP3A4 substrate and weak inhibitor, so the effect on saxagliptin is likely small and the legacy strong-inhibitor dose limit does not clearly apply.
How serious is the interaction between Quinidine and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose and renal function, and watch for metformin adverse effects such as gastrointestinal upset or lactic acidosis. Consider reducing metformin dose if needed.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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