Drug interactions
Quinidine + Umeclidinium-vilanterol
Severity: Major
Quinidine and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine markedly prolongs the QT interval and can cause torsades de pointes. Vilanterol can add to this risk through sympathomimetic cardiac stimulation and beta-agonist-induced hypokalemia.
What this interaction means in plain words
Quinidine and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinidine belongs to Anti Parasitic; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization and adrenergic stimulation, with possible beta-agonist-induced hypokalemia.
What to do
Avoid if possible; if used together, monitor ECG and keep serum potassium and magnesium in the normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Quinidine and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinidine markedly prolongs the QT interval and can cause torsades de pointes. Vilanterol can add to this risk through sympathomimetic cardiac stimulation and beta-agonist-induced hypokalemia.
How serious is the interaction between Quinidine and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used together, monitor ECG and keep serum potassium and magnesium in the normal range.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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