Drug interactions
Quinidine + Vecuronium
Severity: Moderate
Quinidine and Vecuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine can potentiate non-depolarising neuromuscular blockers and has been associated with recurrence of paralysis after apparent recovery. This may result in prolonged blockade or respiratory weakness postoperatively.
What this interaction means in plain words
Quinidine and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Vecuronium belongs to Musculoskeletal.
Why it happens
Quinidine has weak neuromuscular blocking activity, reducing acetylcholine release and postsynaptic sensitivity, which adds to non-depolarising blockade.
What to do
Monitor neuromuscular function with train-of-four and ensure full recovery before extubation; reduce vecuronium dosing as needed and observe for recurarisation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vecuronium
Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Frequently asked questions
Can I take Quinidine with Vecuronium?
MediHelp rates the interaction as moderate. Quinidine and Vecuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine can potentiate non-depolarising neuromuscular blockers and has been associated with recurrence of paralysis after apparent recovery. This may result in prolonged blockade or respiratory weakness postoperatively.
How serious is the interaction between Quinidine and Vecuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with train-of-four and ensure full recovery before extubation; reduce vecuronium dosing as needed and observe for recurarisation.
What other medicines interact with Vecuronium?
MediHelp also lists interactions of Vecuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Vecuronium page.
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