Drug interactions
Quinidine + Venetoclax
Severity: Major
Quinidine and Venetoclax: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-glycoprotein and may increase venetoclax exposure. Higher venetoclax levels can increase the risk of neutropenia and tumor lysis syndrome, especially during dose ramp-up.
What this interaction means in plain words
Quinidine and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinidine belongs to Anti Parasitic; Venetoclax belongs to Miscellaneous.
Why it happens
Inhibition of intestinal P-glycoprotein efflux increases venetoclax absorption and systemic exposure.
What to do
Avoid the combination where possible, particularly during ramp-up. If necessary, reduce the venetoclax dose by at least 50% per labeling and monitor blood counts and for tumor lysis.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Quinidine with Venetoclax?
MediHelp rates the interaction as major. Quinidine and Venetoclax can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinidine inhibits P-glycoprotein and may increase venetoclax exposure. Higher venetoclax levels can increase the risk of neutropenia and tumor lysis syndrome, especially during dose ramp-up.
How serious is the interaction between Quinidine and Venetoclax?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly during ramp-up. If necessary, reduce the venetoclax dose by at least 50% per labeling and monitor blood counts and for tumor lysis.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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