Drug interactions
Quinidine + Vinblastine
Severity: Moderate
Quinidine and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits P-gp and may raise vinblastine exposure, which could increase neurotoxicity and myelosuppression. Evidence comes largely from mechanistic and preclinical data.
What this interaction means in plain words
Quinidine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Vinblastine belongs to Oncology.
Why it happens
Quinidine inhibits P-gp-mediated efflux of vinblastine, increasing its exposure.
What to do
Monitor blood counts and neurological status closely. Consider an alternative antiarrhythmic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Vinblastine
Frequently asked questions
Can I take Quinidine with Vinblastine?
MediHelp rates the interaction as moderate. Quinidine and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits P-gp and may raise vinblastine exposure, which could increase neurotoxicity and myelosuppression. Evidence comes largely from mechanistic and preclinical data.
How serious is the interaction between Quinidine and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurological status closely. Consider an alternative antiarrhythmic.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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