Drug interactions
Quinidine + Voclosporin
Severity: Major
Quinidine and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine is a well-known QT-prolonging antiarrhythmic, and voclosporin has been associated with QT prolongation at supratherapeutic exposures. Combined use may add to the risk of torsades de pointes, particularly with electrolyte disturbances or bradycardia. Quinidine is also a P-gp and CYP2D6 inhibitor, and voclosporin is a CYP3A4 and P-gp substrate, so exposure changes are possible.
What this interaction means in plain words
Quinidine and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinidine belongs to Anti Parasitic; Voclosporin belongs to Miscellaneous.
Why it happens
Additive prolongation of cardiac repolarization (QTc) through pharmacodynamic synergy.
What to do
Obtain a baseline ECG and monitor QTc after starting the combination, and correct potassium and magnesium before and during therapy. Consider an alternative antiarrhythmic if the QTc becomes significantly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Quinidine with Voclosporin?
MediHelp rates the interaction as major. Quinidine and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Quinidine is a well-known QT-prolonging antiarrhythmic, and voclosporin has been associated with QT prolongation at supratherapeutic exposures. Combined use may add to the risk of torsades de pointes, particularly with electrolyte disturbances or bradycardia. Quinidine is also a P-gp and CYP2D6 inhibitor, and voclosporin is a CYP3A4 and P-gp substrate, so exposure changes are possible.
How serious is the interaction between Quinidine and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc after starting the combination, and correct potassium and magnesium before and during therapy. Consider an alternative antiarrhythmic if the QTc becomes significantly prolonged.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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