Drug interactions
Quinidine + Vonoprazan
Severity: Moderate
Quinidine and Vonoprazan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vonoprazan is a weak CYP3A inhibitor and may modestly raise concentrations of quinidine, which is mainly cleared by CYP3A4. Because quinidine has a narrow therapeutic window and can cause QT prolongation, even a small rise in exposure may matter in susceptible patients.
What this interaction means in plain words
Quinidine and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Vonoprazan belongs to Gastrointestinal Tract.
Why it happens
Weak inhibition of CYP3A4-mediated quinidine metabolism by vonoprazan.
What to do
Monitor ECG for QTc prolongation and watch for quinidine toxicity such as cinchonism or arrhythmia. Check quinidine levels if available and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Vonoprazan
- Amobarbital + Vonoprazan Major
- Apalutamide + Vonoprazan Major
- Atazanavir + Vonoprazan Major
- Carbamazepine + Vonoprazan Major
- Erlotinib + Vonoprazan Major
- Phenytoin + Vonoprazan Major
Frequently asked questions
Can I take Quinidine with Vonoprazan?
MediHelp rates the interaction as moderate. Quinidine and Vonoprazan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vonoprazan is a weak CYP3A inhibitor and may modestly raise concentrations of quinidine, which is mainly cleared by CYP3A4. Because quinidine has a narrow therapeutic window and can cause QT prolongation, even a small rise in exposure may matter in susceptible patients.
How serious is the interaction between Quinidine and Vonoprazan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG for QTc prolongation and watch for quinidine toxicity such as cinchonism or arrhythmia. Check quinidine levels if available and adjust the dose accordingly.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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