Drug interactions
Quinidine + Voxelotor
Severity: Major
Quinidine and Voxelotor: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor is a moderate CYP3A4 inhibitor and quinidine is partly metabolized by CYP3A4. Increased quinidine levels may enhance QT prolongation and other toxicity of this narrow therapeutic index drug.
What this interaction means in plain words
Quinidine and Voxelotor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Quinidine belongs to Anti Parasitic; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibition of CYP3A4 reduces quinidine metabolism.
What to do
Avoid the combination when possible. If used, monitor ECG and quinidine concentrations and reduce the quinidine dose as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Quinidine with Voxelotor?
MediHelp rates the interaction as major. Quinidine and Voxelotor can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voxelotor is a moderate CYP3A4 inhibitor and quinidine is partly metabolized by CYP3A4. Increased quinidine levels may enhance QT prolongation and other toxicity of this narrow therapeutic index drug.
How serious is the interaction between Quinidine and Voxelotor?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible. If used, monitor ECG and quinidine concentrations and reduce the quinidine dose as needed.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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