Drug interactions
Quinine + Ritlecitinib
Severity: Moderate
Quinine and Ritlecitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib may inhibit CYP3A4 and could raise quinine exposure. Higher quinine levels increase the risk of cinchonism and QT prolongation.
What this interaction means in plain words
Quinine and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinine belongs to Anti Parasitic; Ritlecitinib belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated quinine metabolism by ritlecitinib.
What to do
Monitor for quinine toxicity such as tinnitus, nausea and palpitations, and consider an ECG in patients with cardiac risk factors. Adjust quinine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Quinine with Ritlecitinib?
MediHelp rates the interaction as moderate. Quinine and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritlecitinib may inhibit CYP3A4 and could raise quinine exposure. Higher quinine levels increase the risk of cinchonism and QT prolongation.
How serious is the interaction between Quinine and Ritlecitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity such as tinnitus, nausea and palpitations, and consider an ECG in patients with cardiac risk factors. Adjust quinine dose if adverse effects appear.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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