Drug interactions
Quinine + Solifenacin
Severity: Moderate
Quinine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine can prolong the QT interval and solifenacin has dose-related QT effects, so combining them may raise the risk of arrhythmia. The risk is greater with electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Quinine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinine belongs to Anti Parasitic; Solifenacin belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check the ECG and electrolytes beforehand and monitor the QTc during quinine treatment. Avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Quinine with Solifenacin?
MediHelp rates the interaction as moderate. Quinine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine can prolong the QT interval and solifenacin has dose-related QT effects, so combining them may raise the risk of arrhythmia. The risk is greater with electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Quinine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the ECG and electrolytes beforehand and monitor the QTc during quinine treatment. Avoid adding further QT-prolonging drugs.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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