Drug interactions
Quinine + Talquetamab
Severity: Moderate
Quinine and Talquetamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release syndrome from talquetamab may transiently suppress CYP enzymes, which could raise quinine concentrations. Higher levels increase the risk of cinchonism and QT prolongation.
What this interaction means in plain words
Quinine and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinine belongs to Anti Parasitic; Talquetamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 reduces quinine metabolism.
What to do
Monitor for quinine toxicity such as tinnitus, QT prolongation and hypoglycemia, especially during step-up dosing and for about two weeks after. Consider an ECG if CRS occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Talquetamab
- Clozapine + Talquetamab Major
- Pimozide + Talquetamab Major
- Bendamustine + Talquetamab Moderate
- Carbamazepine + Talquetamab Moderate
- Clomipramine + Talquetamab Moderate
- Colchicine + Talquetamab Moderate
Frequently asked questions
Can I take Quinine with Talquetamab?
MediHelp rates the interaction as moderate. Quinine and Talquetamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release syndrome from talquetamab may transiently suppress CYP enzymes, which could raise quinine concentrations. Higher levels increase the risk of cinchonism and QT prolongation.
How serious is the interaction between Quinine and Talquetamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity such as tinnitus, QT prolongation and hypoglycemia, especially during step-up dosing and for about two weeks after. Consider an ECG if CRS occurs.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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