Drug interactions
Quinine + Tazemetostat
Severity: Moderate
Quinine and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak CYP3A4 inducer and a CYP3A4 substrate, while quinine is a moderate CYP3A4 inhibitor. Quinine may raise tazemetostat levels, while tazemetostat may slightly lower quinine levels.
What this interaction means in plain words
Quinine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinine belongs to Anti Parasitic; Tazemetostat belongs to Miscellaneous.
Why it happens
Bidirectional CYP3A4 effects: quinine inhibits tazemetostat metabolism and tazemetostat weakly induces quinine metabolism.
What to do
Monitor for tazemetostat adverse effects and for quinine efficacy. Adjust the tazemetostat dose according to its labeling if a moderate CYP3A4 inhibitor is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Quinine with Tazemetostat?
MediHelp rates the interaction as moderate. Quinine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak CYP3A4 inducer and a CYP3A4 substrate, while quinine is a moderate CYP3A4 inhibitor. Quinine may raise tazemetostat levels, while tazemetostat may slightly lower quinine levels.
How serious is the interaction between Quinine and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tazemetostat adverse effects and for quinine efficacy. Adjust the tazemetostat dose according to its labeling if a moderate CYP3A4 inhibitor is needed.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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