Drug interactions
Quinupristin / dalfopristin + Temsirolimus
Severity: Moderate
Quinupristin / dalfopristin and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may increase concentrations of temsirolimus and its metabolite sirolimus. This raises the potential for mTOR inhibitor toxicity.
What this interaction means in plain words
Quinupristin / dalfopristin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of temsirolimus and sirolimus.
What to do
Monitor for temsirolimus adverse effects such as cytopenias, mucositis and hyperglycemia. Consider an alternative antibiotic if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Quinupristin / dalfopristin with Temsirolimus?
MediHelp rates the interaction as moderate. Quinupristin / dalfopristin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4 and may increase concentrations of temsirolimus and its metabolite sirolimus. This raises the potential for mTOR inhibitor toxicity.
How serious is the interaction between Quinupristin / dalfopristin and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for temsirolimus adverse effects such as cytopenias, mucositis and hyperglycemia. Consider an alternative antibiotic if toxicity develops.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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