Drug interactions
Quinupristin / dalfopristin + Trazodone
Severity: Moderate
Quinupristin / dalfopristin and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4, which is the main pathway for trazodone's conversion to its active metabolite and its clearance. Trazodone exposure may rise, increasing sedation, hypotension and possibly QT-related risk.
What this interaction means in plain words
Quinupristin / dalfopristin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated trazodone metabolism.
What to do
Monitor for excess sedation, orthostatic hypotension and arrhythmia symptoms during the antibiotic course. Consider reducing the trazodone dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Quinupristin / dalfopristin with Trazodone?
MediHelp rates the interaction as moderate. Quinupristin / dalfopristin and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinupristin/dalfopristin inhibits CYP3A4, which is the main pathway for trazodone's conversion to its active metabolite and its clearance. Trazodone exposure may rise, increasing sedation, hypotension and possibly QT-related risk.
How serious is the interaction between Quinupristin / dalfopristin and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, orthostatic hypotension and arrhythmia symptoms during the antibiotic course. Consider reducing the trazodone dose if adverse effects appear.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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