Drug interactions
Quinupristin / dalfopristin + Zonisamide
Severity: Minor
Quinupristin / dalfopristin and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and could raise zonisamide concentrations. The effect is theoretical and short-lived given the limited duration of IV therapy.
What this interaction means in plain words
Quinupristin / dalfopristin and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 by quinupristin/dalfopristin may reduce zonisamide metabolism.
What to do
Observe for increased sedation, dizziness or confusion during the antibiotic course. Reduce the zonisamide dose only if toxicity appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Quinupristin / dalfopristin and Zonisamide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Quinupristin / dalfopristin with Zonisamide?
MediHelp rates the interaction as minor. Quinupristin / dalfopristin and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4 and could raise zonisamide concentrations. The effect is theoretical and short-lived given the limited duration of IV therapy.
How serious is the interaction between Quinupristin / dalfopristin and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe for increased sedation, dizziness or confusion during the antibiotic course. Reduce the zonisamide dose only if toxicity appears.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
