Drug interactions
Rabeprazole + Rucaparib
Severity: Minor
Rabeprazole and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP2C19 and CYP3A4 weakly to moderately, and these are minor pathways for rabeprazole. Any increase in rabeprazole exposure is likely small and of little consequence given its wide safety margin.
What this interaction means in plain words
Rabeprazole and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rabeprazole belongs to Gastrointestinal Tract; Rucaparib belongs to Oncology.
Why it happens
Rucaparib inhibits CYP2C19 and CYP3A4, minor routes of rabeprazole metabolism.
What to do
No routine adjustment is needed; monitor for PPI-related adverse effects during long-term co-use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Rabeprazole with Rucaparib?
MediHelp rates the interaction as minor. Rabeprazole and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP2C19 and CYP3A4 weakly to moderately, and these are minor pathways for rabeprazole. Any increase in rabeprazole exposure is likely small and of little consequence given its wide safety margin.
How serious is the interaction between Rabeprazole and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for PPI-related adverse effects during long-term co-use.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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