Drug interactions
Rabeprazole + Stiripentol
Severity: Minor
Rabeprazole and Stiripentol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol inhibits CYP2C19 and has mixed effects on CYP3A4, which could modestly alter rabeprazole exposure. Rabeprazole is mainly cleared non-enzymatically, so the effect is probably small.
What this interaction means in plain words
Rabeprazole and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rabeprazole belongs to Gastrointestinal Tract; Stiripentol belongs to Central Nervous System.
Why it happens
Stiripentol inhibits CYP2C19 and CYP3A4, minor pathways for rabeprazole.
What to do
No empirical dose change is needed; adjust the rabeprazole dose according to symptom control and tolerability.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Stiripentol
Frequently asked questions
Can I take Rabeprazole with Stiripentol?
MediHelp rates the interaction as minor. Rabeprazole and Stiripentol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Stiripentol inhibits CYP2C19 and has mixed effects on CYP3A4, which could modestly alter rabeprazole exposure. Rabeprazole is mainly cleared non-enzymatically, so the effect is probably small.
How serious is the interaction between Rabeprazole and Stiripentol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; adjust the rabeprazole dose according to symptom control and tolerability.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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