Drug interactions
Rabeprazole + Triclabendazole
Severity: Minor
Rabeprazole and Triclabendazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triclabendazole may inhibit CYP2C19 and could modestly raise exposure to CYP2C19 substrates. Rabeprazole depends little on this enzyme, so a significant effect is unlikely.
What this interaction means in plain words
Rabeprazole and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Rabeprazole belongs to Gastrointestinal Tract; Triclabendazole belongs to Anti Parasitic.
Why it happens
Possible CYP2C19 inhibition by triclabendazole affects a minor metabolic route of rabeprazole.
What to do
No dose adjustment is needed. Monitor for PPI adverse effects during the short course of triclabendazole.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rabeprazole
- Rabeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Rabeprazole Major
- Atazanavir + Rabeprazole Major
- Dacomitinib + Rabeprazole Major
- Dasatinib + Rabeprazole Major
- Erlotinib + Rabeprazole Major
Other interactions of Triclabendazole
Frequently asked questions
Can I take Rabeprazole with Triclabendazole?
MediHelp rates the interaction as minor. Rabeprazole and Triclabendazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Triclabendazole may inhibit CYP2C19 and could modestly raise exposure to CYP2C19 substrates. Rabeprazole depends little on this enzyme, so a significant effect is unlikely.
How serious is the interaction between Rabeprazole and Triclabendazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for PPI adverse effects during the short course of triclabendazole.
What other medicines interact with Rabeprazole?
MediHelp also lists interactions of Rabeprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Rabeprazole page.
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