Drug interactions
Ramelteon + Rifapentine
Severity: Moderate
Ramelteon and Rifapentine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces CYP3A4 and CYP2C enzymes and can lower ramelteon exposure, since the strong inducer rifampin markedly reduces it. Ramelteon may become ineffective for insomnia.
What this interaction means in plain words
Ramelteon and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ramelteon belongs to Central Nervous System; Rifapentine belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 and CYP2C9 by rifapentine increases ramelteon clearance.
What to do
Monitor for loss of hypnotic efficacy and consider an alternative sleep agent if ramelteon fails.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Ramelteon with Rifapentine?
MediHelp rates the interaction as moderate. Ramelteon and Rifapentine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifapentine induces CYP3A4 and CYP2C enzymes and can lower ramelteon exposure, since the strong inducer rifampin markedly reduces it. Ramelteon may become ineffective for insomnia.
How serious is the interaction between Ramelteon and Rifapentine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of hypnotic efficacy and consider an alternative sleep agent if ramelteon fails.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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