Drug interactions
Ramelteon + Sufentanil
Severity: Moderate
Ramelteon and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a potent opioid, and adding ramelteon may increase sedation. Ramelteon does not cause meaningful respiratory depression itself, so the added risk is mainly drowsiness.
What this interaction means in plain words
Ramelteon and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ramelteon belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS depression; no pharmacokinetic interaction is established.
What to do
Monitor sedation level and respiratory status when ramelteon is used with sufentanil. Reduce doses if excess sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Ramelteon with Sufentanil?
MediHelp rates the interaction as moderate. Ramelteon and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sufentanil is a potent opioid, and adding ramelteon may increase sedation. Ramelteon does not cause meaningful respiratory depression itself, so the added risk is mainly drowsiness.
How serious is the interaction between Ramelteon and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory status when ramelteon is used with sufentanil. Reduce doses if excess sedation develops.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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