Drug interactions
Ramelteon + Thioridazine
Severity: Minor
Ramelteon and Thioridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine is strongly sedating, and ramelteon adds hypnotic activity, so drowsiness and psychomotor impairment may be greater. The more serious concern with thioridazine is QT prolongation, but ramelteon does not add to that risk.
What this interaction means in plain words
Ramelteon and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ramelteon belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression via antihistaminic and alpha-adrenergic blockade (thioridazine) and melatonin agonism (ramelteon).
What to do
Warn the patient about additive sedation and driving risk. Monitor for excessive daytime drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Ramelteon with Thioridazine?
MediHelp rates the interaction as minor. Ramelteon and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thioridazine is strongly sedating, and ramelteon adds hypnotic activity, so drowsiness and psychomotor impairment may be greater. The more serious concern with thioridazine is QT prolongation, but ramelteon does not add to that risk.
How serious is the interaction between Ramelteon and Thioridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about additive sedation and driving risk. Monitor for excessive daytime drowsiness.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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