Drug interactions
Ramelteon + Verapamil
Severity: Minor
Ramelteon and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil may modestly raise ramelteon exposure, possibly increasing drowsiness or dizziness. The effect is predicted rather than well documented, and the strong CYP1A2 pathway dominates ramelteon clearance.
What this interaction means in plain words
Ramelteon and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ramelteon belongs to Central Nervous System; Verapamil belongs to Cardiovascular.
Why it happens
Minor inhibition of CYP3A4 metabolism of ramelteon.
What to do
No dose change is usually needed; counsel on next-day sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ramelteon with Verapamil?
MediHelp rates the interaction as minor. Ramelteon and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil may modestly raise ramelteon exposure, possibly increasing drowsiness or dizziness. The effect is predicted rather than well documented, and the strong CYP1A2 pathway dominates ramelteon clearance.
How serious is the interaction between Ramelteon and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; counsel on next-day sedation.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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