Drug interactions
Ramelteon + Zafirlukast
Severity: Minor
Ramelteon and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ramelteon is metabolized mainly by CYP1A2, with minor roles for CYP2C and CYP3A4. Zafirlukast's weak inhibition of these enzymes is unlikely to alter ramelteon effects meaningfully.
What this interaction means in plain words
Ramelteon and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ramelteon belongs to Central Nervous System; Zafirlukast belongs to Respiratory.
Why it happens
Possible weak inhibition of CYP2C9 and CYP3A4 by zafirlukast reducing ramelteon clearance.
What to do
No adjustment is needed. Monitor for increased daytime drowsiness or dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Frequently asked questions
Can I take Ramelteon with Zafirlukast?
MediHelp rates the interaction as minor. Ramelteon and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ramelteon is metabolized mainly by CYP1A2, with minor roles for CYP2C and CYP3A4. Zafirlukast's weak inhibition of these enzymes is unlikely to alter ramelteon effects meaningfully.
How serious is the interaction between Ramelteon and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is needed. Monitor for increased daytime drowsiness or dizziness.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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