Drug interactions
Ranolazine + Romidepsin
Severity: Major
Ranolazine and Romidepsin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause QT/T-wave changes and ranolazine also prolongs QT, so combined use may raise the risk of ventricular arrhythmias. Ranolazine inhibits P-gp, which may additionally increase romidepsin exposure.
What this interaction means in plain words
Ranolazine and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation, plus possible P-gp inhibition by ranolazine increasing romidepsin levels.
What to do
Avoid the combination if an alternative is available; otherwise monitor ECG and keep potassium and magnesium within normal range before and during each romidepsin cycle.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Romidepsin?
MediHelp rates the interaction as major. Ranolazine and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Romidepsin can cause QT/T-wave changes and ranolazine also prolongs QT, so combined use may raise the risk of ventricular arrhythmias. Ranolazine inhibits P-gp, which may additionally increase romidepsin exposure.
How serious is the interaction between Ranolazine and Romidepsin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative is available; otherwise monitor ECG and keep potassium and magnesium within normal range before and during each romidepsin cycle.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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