Drug interactions
Ranolazine + Sulfamethoxazole
Severity: Minor
Ranolazine and Sulfamethoxazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfamethoxazole, usually given with trimethoprim, has been associated with rare QT prolongation and arrhythmia, and ranolazine prolongs QT in a dose-related fashion. Clinical significance is generally low in patients without other risk factors.
What this interaction means in plain words
Ranolazine and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive effect on cardiac repolarization.
What to do
No routine change is needed. Check ECG and electrolytes if the patient has other QT risk factors, heart failure or renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Sulfamethoxazole?
MediHelp rates the interaction as minor. Ranolazine and Sulfamethoxazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sulfamethoxazole, usually given with trimethoprim, has been associated with rare QT prolongation and arrhythmia, and ranolazine prolongs QT in a dose-related fashion. Clinical significance is generally low in patients without other risk factors.
How serious is the interaction between Ranolazine and Sulfamethoxazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Check ECG and electrolytes if the patient has other QT risk factors, heart failure or renal impairment.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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