Drug interactions
Ranolazine + Teniposide
Severity: Minor
Ranolazine and Teniposide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein, and teniposide is a P-gp substrate, so teniposide exposure could increase. This may worsen myelosuppression and mucositis, although clinical data are lacking.
What this interaction means in plain words
Ranolazine and Teniposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
P-gp inhibition by ranolazine reducing teniposide efflux.
What to do
Monitor blood counts as part of routine chemotherapy care. Consider dose adjustment of teniposide if unexpected toxicity develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Teniposide?
MediHelp rates the interaction as minor. Ranolazine and Teniposide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine inhibits P-glycoprotein, and teniposide is a P-gp substrate, so teniposide exposure could increase. This may worsen myelosuppression and mucositis, although clinical data are lacking.
How serious is the interaction between Ranolazine and Teniposide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts as part of routine chemotherapy care. Consider dose adjustment of teniposide if unexpected toxicity develops.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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