Drug interactions
Ranolazine + Trifluoperazine
Severity: Moderate
Ranolazine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined use may increase the chance of torsades de pointes, especially with hypokalemia, bradycardia or other QT-prolonging drugs. Ranolazine also weakly inhibits CYP2D6, which could modestly raise exposure to some phenothiazines.
What this interaction means in plain words
Ranolazine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QTc prolongation from both drugs.
What to do
Obtain a baseline ECG and repeat after the combination is started, and correct electrolyte abnormalities. Consider an alternative if the QTc becomes substantially prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Trifluoperazine?
MediHelp rates the interaction as moderate. Ranolazine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combined use may increase the chance of torsades de pointes, especially with hypokalemia, bradycardia or other QT-prolonging drugs. Ranolazine also weakly inhibits CYP2D6, which could modestly raise exposure to some phenothiazines.
How serious is the interaction between Ranolazine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and repeat after the combination is started, and correct electrolyte abnormalities. Consider an alternative if the QTc becomes substantially prolonged.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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